1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index is a method used to quantify insulin resistance and beta-cell function. It provides an assessment of insulin resistance from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/L
• Fasting Glucose — Measured in mmol/L
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance by calculating the product of fasting insulin and glucose levels, normalized by the constant 22.5.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: When should HOMA-IR be measured?
A: After an overnight fast of 8-12 hours, avoiding strenuous exercise and medication that affects glucose metabolism before testing.

Q3: Are there limitations to HOMA-IR?
A: Yes, it's less accurate in individuals with impaired beta-cell function and may not reflect dynamic changes in insulin sensitivity.

Q4: Can HOMA-IR be used for diagnosis?
A: It's primarily used for research and screening purposes rather than definitive diagnosis of insulin resistance.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on clinical context, but typically it's measured during routine metabolic assessments or when monitoring treatment response.