1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index is a method used to quantify insulin resistance and beta-cell function. It provides an assessment of insulin resistance from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/L
• Fasting Glucose — Measured in mmol/L
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance by calculating the product of fasting insulin and glucose levels, normalized by the constant 22.5.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is a valuable tool for assessing insulin resistance, which is associated with various metabolic disorders including type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid (greater than 0).

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Normal HOMA-IR values typically range from 0.5-1.4. Values above 1.9 indicate early insulin resistance, and values above 2.9 indicate significant insulin resistance.

Q2: When should HOMA-IR be measured?
A: HOMA-IR should be calculated from fasting blood samples, ideally collected in the morning after an overnight fast.

Q3: Are there limitations to HOMA-IR?
A: While useful for population studies, HOMA-IR may be less accurate in individuals with impaired glucose tolerance or diabetes, and doesn't account for variations in hepatic glucose production.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is primarily used as a research tool and screening method rather than a definitive diagnostic test for insulin resistance.

Q5: How often should HOMA-IR be monitored?
A: Monitoring frequency depends on individual risk factors and clinical context, typically ranging from every 6 months to annually for at-risk individuals.