1. What Is The HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index is a method used to quantify insulin resistance and beta-cell function. It provides a simple and effective way to assess insulin sensitivity from fasting glucose and insulin measurements.

2. How Does The Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in μU/L (microinternational units per liter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant derived from normal subjects

Explanation: The equation estimates insulin resistance based on the product of fasting insulin and glucose levels, normalized by the constant 22.5.

3. Importance Of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using The Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be positive numbers obtained from fasting blood tests.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0, though this may vary between populations and laboratories.

Q2: When should HOMA-IR be measured?
A: HOMA-IR should be calculated from blood samples taken after an overnight fast of 8-12 hours.

Q3: Are there limitations to HOMA-IR?
A: While useful for population studies, HOMA-IR may be less accurate in individuals with extreme insulin resistance or beta-cell dysfunction.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is primarily used as a screening tool and research measure rather than a definitive diagnostic test.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on clinical context, but typically it's measured during routine metabolic assessments or when monitoring treatment response.