Calcolo Indice HOMA Formula

HOMA-IR Formula:

\[ HOMA-IR = \frac{\text{Fasting Insulin} \times \text{Fasting Glucose}}{22.5} \]

HOMA-IR Index:

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1. What is the HOMA-IR Formula?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It's calculated using fasting insulin and glucose levels to assess insulin sensitivity.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

\[ HOMA-IR = \frac{\text{Fasting Insulin} \times \text{Fasting Glucose}}{22.5} \]

Where:

Fasting Insulin — Measured in μU/L (microinternational units per liter)
Fasting Glucose — Measured in mmol/L (millimoles per liter)
22.5 — Normalization constant

Explanation: The formula estimates insulin resistance by assessing the relationship between fasting insulin and glucose levels. Higher values indicate greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid (greater than 0). For accurate results, measurements should be taken after an overnight fast.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: How does HOMA-IR differ from other insulin resistance tests?
A: HOMA-IR is a simple calculation using fasting values, while other tests like the hyperinsulinemic-euglycemic clamp are more complex but considered the gold standard.

Q3: When should HOMA-IR be measured?
A: It should be measured after an overnight fast of 8-12 hours for accurate results.

Q4: Are there limitations to the HOMA-IR formula?
A: Yes, it may be less accurate in certain populations, such as those with type 1 diabetes, liver disease, or during pregnancy.

Q5: Can HOMA-IR be used for diagnosis?
A: While useful for assessing insulin resistance, it should be used in conjunction with other clinical assessments rather than as a standalone diagnostic tool.