1. What is the HOMA-IR Formula?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides a simple way to assess insulin resistance from fasting glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in μU/mL (microinternational units per milliliter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant

Explanation: The formula calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels. Higher values indicate greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 1.0 indicate normal insulin sensitivity, while values above 2.0 suggest insulin resistance.

Q2: When should HOMA-IR be measured?
A: It should be measured after an overnight fast of 8-12 hours for accurate results.

Q3: Are there limitations to HOMA-IR?
A: Yes, it may not be as accurate in certain populations such as those with type 1 diabetes or advanced liver disease.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, it should not be used alone for clinical diagnosis without additional tests.

Q5: How often should HOMA-IR be tested?
A: Frequency depends on individual risk factors and clinical context, typically as part of metabolic health assessments.