1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in micro international units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Constant derived from normal subjects

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting glucose and insulin levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.0 may indicate insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour fasting period for accurate results.

Q3: Are there limitations to HOMA-IR?
A: HOMA-IR provides an estimate and may not be as accurate as more complex tests like hyperinsulinemic-euglycemic clamp.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, HOMA-IR should be interpreted alongside other clinical findings.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and should be determined by healthcare providers.