1. What is the HOMA-IR Equation?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) equation estimates insulin resistance using fasting insulin and glucose levels. It provides a simple and reliable method to assess insulin sensitivity in clinical practice.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/L (microinternational units per liter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant

Explanation: The equation calculates insulin resistance by multiplying fasting insulin and glucose levels, then dividing by the normalization constant 22.5.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for identifying insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases. Early detection allows for timely intervention and management.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.5 may indicate insulin resistance, and above 5.0 suggest significant insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: HOMA-IR is less accurate in individuals with impaired beta-cell function and may not reflect dynamic changes in insulin sensitivity.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, HOMA-IR should not be used alone for clinical diagnosis. It should be interpreted alongside other clinical findings.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context. It's typically measured during routine metabolic assessments or when monitoring treatment response.