1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance based on fasting insulin and glucose levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/mL (microinternational units per milliliter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels. Higher values indicate greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is a valuable tool for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values typically range from 0.5-1.4. Values above 1.9 indicate early insulin resistance, and values above 2.9 indicate significant insulin resistance.

Q2: When should the test be performed?
A: The test should be performed after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: While useful for population studies and clinical screening, HOMA-IR may not be as accurate as more complex tests like the hyperinsulinemic-euglycemic clamp.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is primarily used as a screening tool and research measure rather than a definitive diagnostic test.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context. It's typically measured during routine metabolic assessments.